CNTROB

centrobin, centriole duplication and spindle assembly protein

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000170037
UniProt:
Q8N137
OMIM:
611425
Synonyms:
LIP8, PP1221

Cilia effects upon perturbation of CNTROB

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=396, lfc=-2.12) PMID:30270045

Subcellular localization

basal body, centrosome, transition zone

References: PMID:41005307, PMID:29440264

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Transition zone

Function

CNTROB has localized in basal body, transition zone.