CNTROB
centrobin, centriole duplication and spindle assembly protein
- Ensembl:
- ENSG00000170037
- UniProt:
- Q8N137
- OMIM:
- 611425
- Synonyms:
- LIP8, PP1221
Cilia effects upon perturbation of CNTROB
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=396, lfc=-2.12) PMID:30270045
Phenotypes
- Mouse ciliopathy phenotype:
- male infertility
Subcellular localization
basal body, centrosome, transition zone
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Transition zone
Function
CNTROB has localized in basal body, transition zone.
Model organism evidence
Drosophila (1 reference)
Centrobin is essential for C-tubule assembly and flagellum development in Drosophila melanogaster spermatogenesis.
PMIDs: 29712734