COBL

cordon-bleu WH2 repeat protein

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000106078
UniProt:: O75128
OMIM:: 610317
Synonyms:: KIAA0633

Cilia effects upon perturbation of COBL

Cilia number / % ciliated:: No effect
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: abnormal thymus morphology, increased effector memory t-helper cell number, enlarged thymus

Subcellular localization

cilia

References: PMID:21129373

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Cobl protein localized apically in ciliated epithelial tissues. In Kupffer's vesicle, the reduction in Cobl coincides with a reduction in the amount of apical F-actin. Cobl represents a molecular activity that couples developmental patterning signals with local intracellular cytoskeletal dynamics to support morphogenesis of motile cilia(21129373).

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