COP1

COP1 E3 ubiquitin ligase

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000143207
UniProt:: Q8NHY2
OMIM:: 608067
Synonyms:: CFAP78, FAP78, FLJ10416, RFWD2, RNF200

Subcellular localization

cilia

Function

The collection of regulators has diverse distributions throughout the cell with Bfar, Cop1, Cul9, Fancg, Skp1a, Uba3, Ube2l3, and Wwp1 showing weak localization to cilia. In addition, Sytl4 localized to the ciliary pocket at the base of the cilium, and Fbxw11 localized to centriolar satellites Positive regulator of Hedgehog signaling (PMID: 34161574).

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