CRB3

crumbs cell polarity complex component 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000130545
UniProt:
Q9BUF7
OMIM:
609737
Synonyms:
MGC17303

Cilia effects upon perturbation of CRB3

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.60) PMID:20393562

Subcellular localization

cilia

References: PMID:17646395, PMID:28882989, PMID:15324661

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cilia length regulation

Function

Epithelial polarity, tight junction formation and ciliogenesis. CRB3-CLPI isoform interacts with importin β-1 to be delivered to spindle poles during cell division and ciliogenesis, and this delivery may be important for centrosomemainte nce (17646395). It modulates intraflagellar transport and cilia elongation together with Par3/Par6/aPKC polarity complex (28882989, 15324661) Moreover, morpholino knockdown of crb3a in zebrafish was shown to reduce cilia length (28882989)