CREB3

cAMP responsive element binding protein 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000107175
UniProt:
O43889
OMIM:
606443
Synonyms:
LUMAN, LZIP, SLZIP

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.59) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.02) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.11) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal epididymis morphology, hyperactivity, preweaning lethality, incomplete penetrance, enlarged epididymis, decreased body length

Ciliopathy associations

  • CREB3-related Syndromic Ciliopathy

Subcellular localization

cilia, cytosol, nucleus, ciliary tip, transition zone, basal body

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

CREB3 has localized in ciliary tip, primary cilia.