CREB3

cAMP responsive element binding protein 3

Ensembl:
ENSG00000107175
UniProt:
O43889
OMIM:
606443
Synonyms:
LUMAN, LZIP, SLZIP

Cilia effects upon perturbation of CREB3

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.59) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.02) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.11) PMID:41160700

Phenotypes

Mouse phenotype:
abnormal epididymis morphology, hyperactivity, preweaning lethality, incomplete penetrance, enlarged epididymis, decreased body length

Subcellular localization

cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

CREB3 has localized in ciliary tip, primary cilia.

Model organism evidence

Drosophila (1 reference)

Specifically, we consider Arf small G proteins, such as Arf1 and Sar1, and their coat effectors, COPI and COPII, and how these proteins promote biosynthetic trafficking for cleavage of the Drosophila embryo, the growth of neuronal dendrites and synapses, extracellular matrix secretion for bone d

PMIDs: 28410007