CRHR2

corticotropin releasing hormone receptor 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000106113
UniProt:
Q13324
OMIM:
602034
Synonyms:
CRF-RB, CRF2, HM-CRF

Cilia effects upon perturbation of CRHR2

Loss-of-function effect:
No effect

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.60) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia

References: PMID:26167768

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Mammalian G-protein coupled receptor (GPCR) with high affinity for corticotropin-releasing hormone (CRH) and the CRH family of peptides, involved in neurotransmitters signaling. Component of ciliogenesis pathways. Studies suggest that GPCRs may regulate endocytic membrane trafficking, playing sensory or signalling roles in the ciliary vesicle or procilium at the earliest stages of ciliogenesis both in the developing brain and in other tissues.