CRISP2

cysteine rich secretory protein 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000124490
UniProt:: P16562
OMIM:: 187430
Synonyms:: CRISP-2, CT36, GAPDL5, TPX1

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

Male Infertility

References: PMID:35207567

Subcellular localization

flagella

References: PMID:35207567, PMID:36054334

Functional category

Metabolism

Function

The immunofluorescent staining of CRISP2 of zona bound sperm that CRISP2 had a location on the apical ridge, the EqS, the post acrosomal region and the sperm tail. The loss of CRISP2 immunofluorescence from the EqS after ionophore A23187 induced acrosome reaction suggests that CRISP2 is not directly involved in sperm-egg fusion at this site(PMID: 36054334).

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