CRISP2

cysteine rich secretory protein 2

Ensembl:
ENSG00000124490
UniProt:
P16562
OMIM:
187430
Synonyms:
CRISP-2, CT36, GAPDL5, TPX1

Cilia effects upon perturbation of CRISP2

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Male Infertility

Subcellular localization

flagella

Functional category

  • Metabolism

Function

The immunofluorescent staining of CRISP2 of zona bound sperm that CRISP2 had a location on the apical ridge, the EqS, the post acrosomal region and the sperm tail. The loss of CRISP2 immunofluorescence from the EqS after ionophore A23187 induced acrosome reaction suggests that CRISP2 is not directly involved in sperm-egg fusion at this site(PMID: 36054334).

Model organism evidence

Mus musculus (1 reference)

The net power input from the dynein motors in sperm from Crisp2-knockout mice is significantly smaller than in wildtype samples, indicating that ion-channel regulation by cysteine-rich secretory proteins controls energy flows powering the axoneme.

PMIDs: 33929317