CRK

CRK proto-oncogene, adaptor protein

Ensembl:
ENSG00000167193
UniProt:
P46108
OMIM:
164762

Cilia effects upon perturbation of CRK

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.45) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

CRK has localized in basal body. CRK plays role in RTK signaling pathway (GO:0007169) and Mitogen-activated protein kinase (MAPK) cascade (GO:0000165) as a basal body protein (41005307)