CROCC

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

decreased exploration in new environment

Subcellular localization

basal body, centrosome, cilia, transition zone

References: PMID:41005307, PMID:12427867, PMID:15870283, PMID:23070519, PMID:24094853

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)
• Transition zone

Function

Structural component of the ciliary rootlet. Coiled-coil interaction in the extended α-helical rod domain of rootletin is a key feature in rootlet formation (12427867). Interaction between the rootlet and intermediate filaments may contribute substantially to the role as support structure for the cillium. Candidate gene for human retinal degeneration (15870283). interacts with the large coiled-coil protein, C-NAP1, to connect parental centrioles and maintain centrosome cohesion. Positive regulation of ciliogenesis (23070519). CHE-10/rootletin maintains ciliary integrity by modulating the assembly, motility, and flux of IFT particles, which are critical for axoneme length control, and is essential for stabilizing ciliary transition zones and basal bodies (24094853)