CROCC2

ciliary rootlet coiled-coil, rootletin family member 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000226321
UniProt:: H7BZ55

Cilia effects upon perturbation of CROCC2

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Longer cilia
Overexpression effect:: Shorter cilia

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal spleen morphology, enlarged spleen

Subcellular localization

basal body

References: PMID:41410385, PMID:42010243, PMID:25139857, PMID:36334595

Functional category

Ciliary assembly/disassembly

Function

AC104809.3 (LOC728763) ,Foxj1-induced genes, localized along the extracellular shafts of the motile cilia (25139857). IFT20 gain of function could completely block the effects of CROCCP2 on ciliary length (36334595)

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