CROCC2
ciliary rootlet coiled-coil, rootletin family member 2
- Ensembl:
- ENSG00000226321
- UniProt:
- H7BZ55
Cilia effects upon perturbation of CROCC2
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Longer cilia
- Overexpression effect:
- Shorter cilia
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- abnormal spleen morphology, enlarged spleen
- Mouse ciliopathy phenotype:
- abnormal heart morphology, enlarged heart, abnormal kidney morphology
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
Function
AC104809.3 (LOC728763) ,Foxj1-induced genes, localized along the extracellular shafts of the motile cilia (25139857). IFT20 gain of function could completely block the effects of CROCCP2 on ciliary length (36334595)