CROCCP2

Cilia effects upon perturbation of CROCCP2

Loss-of-function effect:

Longer cilia

Overexpression effect:

Decreased

Subcellular localization

cilia associated gene

Functional category

• Ciliary assembly/disassembly
• Neurogenesis & migration

Function

Loss of function of CROCCP2 in human cortical cells and organoids leads to increased ciliogenesis, decreased mTOR signaling, and impaired basal progenitor amplification. These data identify CROCCP2 as a human-specific modifier of cortical neurogenesis that acts through modulation of ciliary dynamics and mTOR signaling(36334595).