CRP

C-reactive protein

Ensembl:: ENSG00000132693
UniProt:: P02741
OMIM:: 123260
Synonyms:: PTX1

Cilia effects upon perturbation of CRP

Cilia number / % ciliated:: Incrased cilia number
Overexpression effect:: Longer cilia

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.66) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, endosome

Functional category

Ciliary assembly/disassembly
Signaling (Hedgehog, GPCRs, ion channels)

Function

CRP inhibits the osteoblastic differentiation of OPCs via the up-regulation of primary cilia and repression of the Hedgehog sig ling pathway ( 38345752).

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