CSNK1D

casein kinase 1 delta

Ensembl:
ENSG00000141551
UniProt:
P48730
OMIM:
600864
Synonyms:
CKID, CKIDELTA, HCKID

Cilia effects upon perturbation of CSNK1D

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, centrosome, cilia, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Protein processing & maturation

Function

Also called CKI-delta. Required for microtubule nucleation at the Golgi and mainte nce of Golgi integrity. It mediates primary ciliogenesis by multiple mechanisms involving its centrosomal function and another dependent on its interaction with AKAP450 at the Golgi, where it is important for maintaining Golgi organization and polarized trafficking of multiple factors that mediate ciliary transport. Required for proper positioning of centriolar satellite proteins (24648492). Csnk1d-null embryos revealed a decline in ciliary length of neural progenitor and RPE cells.

Model organism evidence

Mus musculus (1 reference)

Mouse embryonic fibroblasts (MEFs) and retinal cells from Csnk1d (CK1δ)-null mice also exhibit ciliogenesis defects.

PMIDs: 24648492