CSNK1G1
casein kinase 1 gamma 1
- Ensembl:
- ENSG00000169118
- UniProt:
- Q9HCP0
- OMIM:
- 606274
- Synonyms:
- CK1GAMMA1
Cilia effects upon perturbation of CSNK1G1
Ciliogenesis screen results (4 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.42) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.40) PMID:41160700
Phenotypes
- Mouse phenotype:
- increased leukocyte cell number, increased mean corpuscular hemoglobin, increased grip strength, hyperactivity, increased exploration in new environment, increased mean corpuscular volume
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
Function
CSNK1G1 and CSNK1G3 highly specificly localized to neuronal primary cilia (PMID: 40623838).
Model organism evidence
Drosophila (1 reference)
Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
PMIDs: 27280464