CSNK1G3

casein kinase 1 gamma 3

Ensembl:
ENSG00000151292
UniProt:
Q9Y6M4
OMIM:
604253

Cilia effects upon perturbation of CSNK1G3

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.58) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased mean corpuscular hemoglobin, absent pin reflex, decreased circulating fructosamine level, decreased hematocrit, decreased bone mineral content, decreased body length, decreased erythrocyte cell number, decreased circulating alkaline phosphatase level, increased circulating ldl cholesterol level
Mouse ciliopathy phenotype:
abnormal cranium morphology, abnormal auditory brainstem response

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

CSNK1G1 and CSNK1G3 highly specificly localized to neuronal primary cilia (PMID: 40623838).

Model organism evidence

Drosophila (1 reference)

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.

PMIDs: 27280464