CUL3

cullin 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000036257
OMIM:: 603136

Subcellular localization

basal body, Nucleoplasm, Microtubules, Cytokinetic bridge

References: PMID:25270598

Functional category

Protein processing & maturation
Non-motile cilium / primary cilium
Ciliary assembly/disassembly

Function

Ciliogenesis is blocked if centriolar trichoplein is stabilized by treatment with proteasome inhibitors or by expression of non-ubiquitylatable trichoplein mutant (K50/57R). Started from two-stepped global E3 screening, we have identified KCTD17 as a substrate-adaptor for Cul3-RING E3 ligases (CRL3s) that polyubiquitylates trichoplein. Depletion of KCTD17 specifically arrests ciliogenesis at the initial step of axoneme extension through aberrant trichoplein-Aurora-A activity. Thus, CRL3-KCTD17 targets trichoplein to proteolysis to initiate the axoneme extension during ciliogenesis(25270598).

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