CX3CL1
C-X3-C motif chemokine ligand 1
- Ensembl:
- ENSG00000006210
- UniProt:
- P78423
- OMIM:
- 601880
- Synonyms:
- ABCD-3, C3XKINE, CXC3, CXC3C, NTN
Cilia effects upon perturbation of CX3CL1
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.78) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- decreased locomotor activity, increased respiratory quotient, decreased vertical activity, decreased exploration in new environment
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Neurogenesis & migration
- Viral interactions
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
Function
CX3CR1 is expressed in the motile cilia of differentiated human airway epithelial (HAE) cells and CX3CR1 is expressed in differentiated human ciliated airway cells and co-localizes with respiratory syncytial virus on cilia in a G protein-dependent manner(26107373).