CX3CL1

C-X3-C motif chemokine ligand 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000006210
UniProt:
P78423
OMIM:
601880
Synonyms:
ABCD-3, C3XKINE, CXC3, CXC3C, NTN, SCYD1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.78) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased locomotor activity, increased respiratory quotient, decreased vertical activity, decreased exploration in new environment

Subcellular localization

cilia

References: PMID:26107373

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

CX3CR1 is expressed in the motile cilia of differentiated human airway epithelial (HAE) cells and CX3CR1 is expressed in differentiated human ciliated airway cells and co-localizes with respiratory syncytial virus on cilia in a G protein-dependent manner(26107373).