CXCL5
C-X-C motif chemokine ligand 5
- Ensembl:
- ENSG00000163735
- UniProt:
- P42830
- OMIM:
- 600324
- Synonyms:
- ENA-78, SCYB5
Cilia effects upon perturbation of CXCL5
Ciliogenesis screen results (1 screen)
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- decreased startle reflex, hyperactivity
- Mouse ciliopathy phenotype:
- increased circulating alanine transamise level
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Mechanical stimulation inhibits osteoclast recruitment and differentiation through CXCL5, while PTH1R activation regulate these processes via IL-6 ( 35933642).