CXCR2

Cilia effects upon perturbation of CXCR2

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:

increased gamma-delta t cell number, increased circulating total protein level, decreased mature b cell number, increased leukocyte cell number, increased monocyte cell number, decreased mean corpuscular hemoglobin, increased ly6c low monocyte number, increased klrg1+ cd8 alpha-beta t cell number, increased eosinophil cell number, increased cd103-positive cd11b-low dendritic cell number, increased red blood cell distribution width, decreased cd8-positive, alpha-beta t cell number, increased cd8-positive, alpha-beta memory t cell number, increased memory-marker gamma-delta t cell number, increased memory-marker nk cell number, increased cd4-positive, alpha-beta memory t cell number, decreased b cell number, increased circulating calcium level, decreased t cell number, increased effector memory t-helper cell number, improved glucose tolerance, increased neutrophil cell number, decreased pre-pro b cell number, increased circulating magnesium level, increased granulocyte number, increased anti-nuclear antigen antibody level, thrombocytosis, increased klrg1+ cd4 alpha-beta t cell number, increased memory-marker cd4-positive nk t cell number, increased ly6c high monocyte number, decreased immature b cell number, decreased circulating serum albumin level, decreased pre-b cell number, decreased circulating fructosamine level, decreased circulating thyroxine level, increased effector memory cd8-positive, alpha-beta t cell number

Mouse ciliopathy phenotype:

increased circulating creatinine level

Subcellular localization

basal body, cilia

Functional category

• Ciliary assembly/disassembly
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)

Function

CXCR2 has localized in basal body, cilia.