CXCR4

C-X-C motif chemokine receptor 4

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000121966
UniProt:
P61073
OMIM:
162643
Synonyms:
CD184, D2S201E, FUSIN, HM89, HSY3RR, LESTR, NPY3R, NPYR, NPYY3R

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.04) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance, abnormal blood vessel morphology, increased leukocyte cell number, edema, abnormal limb morphology, decreased circulating creatinine level, abnormal placenta size, embryonic growth retardation, abnormal placenta morphology, increased monocyte cell number, increased lymphocyte cell number, abnormal skin morphology, abnormal eyelid morphology

Subcellular localization

cilia, endosome

References: PMID:41005307, PMID:23153492

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Viral interactions
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

CXCR4, receptor for CXCL12, localized to primary cilia(23153492).