CXCR4
C-X-C motif chemokine receptor 4
- Ensembl:
- ENSG00000121966
- UniProt:
- P61073
- OMIM:
- 162643
- Synonyms:
- CD184, D2S201E, FUSIN, HM89, HSY3RR
Cilia effects upon perturbation of CXCR4
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.04) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- preweaning lethality, complete penetrance, abnormal blood vessel morphology, increased leukocyte cell number, edema, abnormal limb morphology, decreased circulating creatinine level, abnormal placenta size, embryonic growth retardation, abnormal placenta morphology, increased monocyte cell number, increased lymphocyte cell number, abnormal skin morphology, abnormal eyelid morphology
- Mouse ciliopathy phenotype:
- enlarged testis, abnormal kidney morphology, enlarged kidney, abnormal vitreous body morphology, persistence of hyaloid vascular system, cataract, abnormal testis morphology, microphthalmia
Subcellular localization
cilia, endosome
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Neurogenesis & migration
- Viral interactions
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Muscle contraction & physiology
Function
CXCR4, receptor for CXCL12, localized to primary cilia(23153492).
Model organism evidence
Mus musculus (1 reference)
Olfactory sensory neurons (OSNs) are bipolar neurons, unusual because they turn over continuously and have a multiciliated dendrite.
PMIDs: 33075817
Danio rerio (1 reference)
Here, we show that chemokine receptor Cxcr4a is required for L-R laterality by controlling DFC proliferation and KV ciliogenesis.
PMIDs: 31430272