CYB5R3

cytochrome b5 reductase 3

Ensembl:: ENSG00000100243
UniProt:: P00387
OMIM:: 613213
Synonyms:: B5R, DIA1

Cilia effects upon perturbation of CYB5R3

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.22) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, decreased fasting circulating glucose level
Mouse ciliopathy phenotype:: cataract

Subcellular localization

cytosol, endoplasmic reticulum, endosome, flagella, mitochondria

Function

CYB5R3 has localized in flagella.

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