CYLD

CYLD lysine 63 deubiquitinase

Ensembl:
ENSG00000083799
UniProt:
Q9NQC7
OMIM:
605018
Synonyms:
CYLD1, KIAA0849, USPL2

Cilia effects upon perturbation of CYLD

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
No effect
Overexpression effect:
Unknown

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.05) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased locomotor activity, increased basophil cell number, increased grip strength, increased eosinophil cell number, decreased exploration in new environment

Subcellular localization

basal body, centrosome, cytosol, microtubules, nucleus, transition zone

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transition zone
  • Transcription regulation

Function

Deconjugation of the polyubiquitin chain from centrosomal protein Cep70 and promotes ciliogenesis by inhibiting the tubulin deacetylase activity of HDAC6. Regulation of the docking of basal bodies to the apical plasma membrane. CYLD is also required for proper organization of basal bodies and axenomes (25342559). CYLD may control the centriolar satellites proteostasis by preventing the proteasomal degradation of PCM1 (31067453).

Model organism evidence

Mus musculus (2 references)

In addition, the diminished α-tubulin acetylation and impaired sonic hedgehog signaling caused by loss of Cyld were largely restored by simultaneous deletion of Hdac6.

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.

PMIDs: 27028867, 25342559