CYP7A1
cytochrome P450 family 7 subfamily A member 1
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000167910
- UniProt:
- P22680
- OMIM:
- 118455
- Synonyms:
- CYP7
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- decreased circulating iron level, increased circulating alkaline phosphatase level, increased circulating hdl cholesterol level, decreased circulating serum albumin level, increased circulating cholesterol level, decreased blood urea nitrogen level, increased startle reflex, increased circulating unsaturated transferrin level, increased leukocyte cell number, decreased exploration in new environment
Subcellular localization
basal body
References: PMID:33284321
Functional category
- Ciliary assembly/disassembly
- Signaling (Hedgehog, GPCRs, ion channels)
Function
Hedgehog stimulation positively regulates the oxysterol synthase CYP7A1, which accumulates near the ciliary base and produces oxysterols that promote Hedgehog signaling in response to pathway activation (33284321).