DACT1

dishevelled binding antagonist of beta catenin 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000165617
UniProt:
Q9NYF0
OMIM:
607861
Synonyms:
DAPPER, DAPPER1, FRODO, HDPR1, THYEX3

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.30) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Ciliopathy associations

  • Townes-Brocks Syndrome

References: PMID:38296632, PMID:28054444, PMID:36066768

Subcellular localization

nucleus

Functional category

  • Ciliary assembly/disassembly
  • Transcription regulation

Function

Mutations in the DACT1 gene cause Townes-Brocks Syndrome (PMID: 36066768).