DCC

DCC netrin 1 receptor

Ensembl:
ENSG00000187323
UniProt:
P43146
OMIM:
120470
Synonyms:
IGDCC1, NTN1R1

Cilia effects upon perturbation of DCC

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased neutrophil cell number, preweaning lethality, complete penetrance

Subcellular localization

basal body, cilia, cytosol

Functional category

  • Ciliary assembly/disassembly
  • Neurogenesis & migration
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Axon guidance & growth

Function

DCC has localized in primary cilia ,basal body.

Model organism evidence

Mus musculus (1 reference)

This study identifies neuronal primary cilia as critical regulators of stress-induced depressive-like behavior.

PMIDs: 40203655