DCDC2C
doublecortin domain containing 2C
- Ensembl:
- ENSG00000214866
- UniProt:
- A8MYV0
Cilia effects upon perturbation of DCDC2C
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- abnormal vertebrae morphology
- Mouse ciliopathy phenotype:
- increased heart weight
Subcellular localization
flagella
Functional category
- Actin & cytoskeleton regulation
- Reproduction & sperm
Function
DCDC2C has localized in flagella.
Model organism evidence
C. elegans (2 references)
elegans RPI-1 localizes to the entire ciliary axoneme, but is not present in the transition zone and basal body.
Using whole-organism RNA-Seq libraries, we discovered a signature expression profile highly enriched for transcripts of known ciliary proteins, including FAM-161 (FAM161A orthologue), CCDC-104 (CCDC104), and RPI-1 (RP1/RP1L1), which we confirm are cilium-localised in worms.