DCP1A

Cilia effects upon perturbation of DCP1A

Cilia number / % ciliated:

No effect

Loss-of-function effect:

No effect

Ciliogenesis screen results (2 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.81) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.97) PMID:29459680

Subcellular localization

cytoplasmic bodies

References: PMID:28887031

Functional category

• Ciliary morphology regulation
• mRNA metabolism

Function

In C. elegans, the mRNA-decapping enzymes DCAP-1 and DCAP-2 - homologues of mammalian DCP1 and DCP2 respectively - are required for formation of dual rod-type and wing-like shaped cilia; rescue experiments place DCAP-2 activity in neurons rather than in the surrounding glial cells (Adachi et al. 2017, PMID 28887031). DCP1A is one of two human DCP1 paralogs and is therefore a candidate orthologue of DCAP-1. Inclusion rests on the C. elegans ciliary-morphology phenotype; no mammalian ciliary localization has been curated.