DCP1B

decapping mRNA 1B

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000151065
UniProt:
Q8IZD4
OMIM:
609843
Synonyms:
FLJ31638

Cilia effects upon perturbation of DCP1B

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.63) PMID:41160700

Subcellular localization

cytosol, vesicles

References: PMID:28887031

Functional category

  • Ciliary morphology regulation
  • mRNA metabolism

Function

In C. elegans, the mRNA-decapping enzymes DCAP-1 and DCAP-2 - homologues of mammalian DCP1 and DCP2 respectively - are required for formation of dual rod-type and wing-like shaped cilia; rescue experiments place DCAP-2 activity in neurons rather than in the surrounding glial cells (Adachi et al. 2017, PMID 28887031). DCP1B is one of two human DCP1 paralogs and is therefore a candidate orthologue of DCAP-1. Inclusion rests on the C. elegans ciliary-morphology phenotype; no mammalian ciliary localization has been curated.