DCP2

decapping mRNA 2

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000172795
UniProt:: Q8IU60
OMIM:: 609844
Synonyms:: NUDT20

Cilia effects upon perturbation of DCP2

Cilia number / % ciliated:: No effect
Loss-of-function effect:: No effect

Ciliogenesis screen results (4 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-1.53) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=749, lfc=-2.20) PMID:30270045

Phenotypes

Mouse phenotype:: abnormal coat/hair pigmentation; increased heart weight; preweaning lethality; complete penetrance

Subcellular localization

cell junctions, cytoplasmic bodies, nucleoplasm

References: PMID:28887031

Functional category

Ciliary morphology regulation
mRNA metabolism

Function

In C. elegans, the mRNA-decapping enzymes DCAP-1 and DCAP-2 - homologues of mammalian DCP1 and DCP2 respectively - are required for formation of dual rod-type and wing-like shaped cilia; rescue experiments place DCAP-2 activity in neurons rather than in the surrounding glial cells (Adachi et al. 2017, PMID 28887031). DCP2 is the human orthologue of DCAP-2. Inclusion rests on the C. elegans ciliary-morphology phenotype; no mammalian ciliary localization has been curated.

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