DCTN2

dynactin subunit 2

Ensembl:
ENSG00000175203
UniProt:
Q13561
OMIM:
607376
Synonyms:
DCTN-50, RBP50

Cilia effects upon perturbation of DCTN2

Ciliogenesis screen results (6 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.78) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, neg_rank=510, lfc=-2.51) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.65) PMID:41160700

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body, centrosome, cytosol, microtubules

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

DCTN2 has localized in basal body.