DDC

dopa decarboxylase

Ensembl:: ENSG00000132437
UniProt:: P20711
OMIM:: 107930
Synonyms:: AADC

Cilia effects upon perturbation of DDC

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, abnormal tooth morphology, decreased mean corpuscular hemoglobin concentration

Subcellular localization

cilia, cytosol

Functional category

Ciliary assembly/disassembly

Function

DCC has localized in primary cilia ,basal body.

Model organism evidence

C. elegans (1 reference)

Here, we investigate the consequences of CFH and CFH-1 loss-of-function mutations on the dynamics and localization of intraflagellar transport (IFT) train and visual cycle components in these cells.

PMIDs: 41278837

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