DDC

dopa decarboxylase

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000132437
UniProt:: P20711
OMIM:: 107930
Synonyms:: AADC

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, complete penetrance, abnormal tooth morphology, decreased mean corpuscular hemoglobin concentration

Subcellular localization

cilia, cytosol

References: PMID:41005307, Human Protein Atlas

Functional category

Ciliary assembly/disassembly

Function

DDC (dopa decarboxylase) was detected in the primary cilium in a spatial proteomics study of primary cilia (Hansen et al., 2025, Cell, PMID 41005307), and the Human Protein Atlas also places it at the primary cilium.

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.