DDX3X

DEAD-box helicase 3 X-linked

Ensembl:
ENSG00000215301
UniProt:
O00571
OMIM:
300160
Synonyms:
CAP-RF, DBX, DDX14, DDX3, HLP2

Cilia effects upon perturbation of DDX3X

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.86) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
X-linked non-syndromic intellectual disability; X-linked intellectual disability-hypotonia-movement disorder syndrome; Intellectual disability

Ciliopathy associations

  • Medulloblastoma

Subcellular localization

cytosol

Functional category

  • Motile cilium & axoneme

Function

Mutations in DDX3X cause Medulloblastoma (PMID: 39062517).