DEGS1

delta 4-desaturase, sphingolipid 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000143753
UniProt:: O15121
OMIM:: 615843
Synonyms:: DEGS-1, DES-1, DES1, FADS7, MLD

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.36) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

References: PMID:38838665

Functional category

Ciliary assembly/disassembly

Function

The dihydroceramide desaturase DEGS1/2 ortholog TTM-5 is highly expressed in the EV-releasing sensory neurons, localizes to cilia, and is required for sustained but not initial ciliary EV release, implicating ceramide in ciliary ectocytosis(38838665).

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