DEGS1

delta 4-desaturase, sphingolipid 1

Ensembl:
ENSG00000143753
UniProt:
O15121
OMIM:
615843
Synonyms:
DEGS-1, DES-1, DES1, FADS7, MLD

Cilia effects upon perturbation of DEGS1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.36) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

The dihydroceramide desaturase DEGS1/2 ortholog TTM-5 is highly expressed in the EV-releasing sensory neurons, localizes to cilia, and is required for sustained but not initial ciliary EV release, implicating ceramide in ciliary ectocytosis(38838665).

Model organism evidence

C. elegans (1 reference)

Instead, ciliary intrinsic mechanisms regulate PKD-2 ciliary membrane replenishment and dynamic EV release.

PMIDs: 37961114