DENND1B

DENN domain containing 1B

Ensembl:: ENSG00000213047
UniProt:: Q6P3S1
OMIM:: 613292
Synonyms:: C1ORF218, FAM31B, FLJ20054, MGC27044

Cilia effects upon perturbation of DENND1B

Cilia number / % ciliated:: Decreased cilia number
Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Consistent with these observations, GFP-Rab35 localises to cilia, as do GEF (DENND1B) and GAP (TBC1D10A) Rab35 regulators, which also regulate ciliary length and Rab35 ciliary localisation(31432619). DENND1B depletion leads to significantly shorter cilia .

Model organism evidence

Danio rerio (1 reference)

Consistent with these observations, GFP-Rab35 localises to cilia, as do GEF (DENND1B) and GAP (TBC1D10A) Rab35 regulators, which also regulate ciliary length and Rab35 ciliary localisation.

PMIDs: 31432619

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