DEUP1

deuterosome assembly protein 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000165325
UniProt:: Q05D60
OMIM:: 617148
Synonyms:: CCDC67, FLJ25393

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: decreased erythrocyte cell number, decreased body length, decreased hemoglobin content, decreased blood urea nitrogen level, decreased hematocrit

Subcellular localization

basal body

References: PMID:24240477, PMID:24934224

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Multicilin coopts the inhibitory E2fs to activate key components that drive centriole assembly during the centriolar cycle, such as Plk4, Cep152, and Stil, while also activating the expression of deup1, the paralog of cep63 required for centriole assembly via the deuterosome rather than the centriolar pathway(24240477, 24934224)

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