DEUP1
deuterosome assembly protein 1
- Ensembl:
- ENSG00000165325
- UniProt:
- Q05D60
- OMIM:
- 617148
- Synonyms:
- CCDC67, FLJ25393
Cilia effects upon perturbation of DEUP1
Ciliogenesis screen results (1 screen)
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- decreased erythrocyte cell number, decreased body length, decreased hemoglobin content, decreased blood urea nitrogen level, decreased hematocrit
- Mouse ciliopathy phenotype:
- decreased circulating calcium level
Subcellular localization
basal body
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
Function
Multicilin coopts the inhibitory E2fs to activate key components that drive centriole assembly during the centriolar cycle, such as Plk4, Cep152, and Stil, while also activating the expression of deup1, the paralog of cep63 required for centriole assembly via the deuterosome rather than the centriolar pathway(24240477, 24934224)
Model organism evidence
Mus musculus (3 references)
DEUP1 functions as a scaffold for basal foot integrity and planar polarity in multiciliated cells.
Further experiments demonstrated that E2f4 knockdown inhibited Deup1 expression and reduced cilia numbers, while Zmynd10 regulated the E2f4-Deup1 axis by activating the E2f4 promoter.