DHX35

DEAH-box helicase 35

Ensembl:
ENSG00000101452
UniProt:
Q9H5Z1
Synonyms:
C20ORF15, DDX35, FLJ22759, KAIA0875

Cilia effects upon perturbation of DHX35

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.97) PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
preweaning lethality, complete penetrance

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism

Function

In CRCs, cancer cells contained single uniformly shaped CEP250 foci that colocalized with centrosome-associated spliceosome components DHX35(37250316) .