DHX57

DExH-box helicase 57

Ensembl:
ENSG00000163214
UniProt:
Q6P158
Synonyms:
DDX57

Cilia effects upon perturbation of DHX57

Ciliogenesis screen results (4 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.23) PMID:41160700

Phenotypes

Mouse phenotype:
increased total body fat amount, decreased heart weight, decreased lean body mass

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Metabolism

Function

The reciprocal ciliary localization patterns of CKAP2L and DHX57 highlighting region-specific variations in ciliary composition between the dorsal and ventral brain regions(PMID: 40654709).