DIS3L

DIS3 like exosome 3'-5' exoribonuclease

Ensembl:: ENSG00000166938
UniProt:: Q8TF46
OMIM:: 614183
Synonyms:: DIS3L1, FLJ38088, KIAA1955, MGC4562

Cilia effects upon perturbation of DIS3L

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal skin morphology, increased eosinophil cell number, abnormal spleen morphology, preweaning lethality, complete penetrance
Mouse ciliopathy phenotype:: abnormal kidney morphology, enlarged kidney, thick ventricular wall

Subcellular localization

cilia

Functional category

Ciliary assembly/disassembly

Function

DIS3L has localized in cilia.

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