DKK1

dickkopf WNT signaling pathway inhibitor 1

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000107984
OMIM:
605189
Synonyms:
DKK-1, SK

Phenotypes

Mouse phenotype:
thick ventricular wall, abnormal heart morphology, abnormal retina vasculature morphology, enlarged heart

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:33690174

Functional category

  • Signaling (Hedgehog
  • GPCRs
  • ion channels)

Function

Expression of DKK1 inhibited the Wnt/β-catenin signaling pathway and partially rescued osteogenic differentiation of MSCs. In summary, our results suggest that gastric cancer cells might cause bone damage prior to the occurrence of bone metastasis via cilia-dependent activation of the Wnt/β-catenin signaling pathway(33690174).