DLAT

dihydrolipoamide S-acetyltransferase

Ensembl:
ENSG00000150768
UniProt:
P10515
OMIM:
608770
Synonyms:
DLTA, E2, PDC-E2

Cilia effects upon perturbation of DLAT

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.64) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=3.88, ciliated=67.3%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.11) PMID:41160700

Phenotypes

Mouse phenotype:
decreased prepulse inhibition, decreased exploration in new environment, preweaning lethality, complete penetrance

Subcellular localization

flagella, lysosomes, mitochondria

Functional category

  • Signaling (Hedgehog, GPCRs, ion channels)

Function

DLAT has localized in flagella.