DLG1

discs large MAGUK scaffold protein 1

Ensembl:
ENSG00000075711
UniProt:
Q12959
OMIM:
601014
Synonyms:
DJ1061C18.1.1, DLGH1, HDLG, SAP-97, SAP97

Cilia effects upon perturbation of DLG1

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia
Overexpression effect:
no effect

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.37) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol, microtubules, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology
  • Cilia length regulation

Function

DLG1 has localized in basal body. Loss of DLG1 resulted in a significant increase in cilia length.

Model organism evidence

Mus musculus (1 reference)

Here we describe a role for DLG1, a core component of the Scribble polarity complex, in regulating ciliary protein trafficking in kidney epithelial cells.

PMIDs: 37987012