DMC1

DNA meiotic recombinase 1

Ensembl:
ENSG00000100206
UniProt:
Q14565
OMIM:
602721
Synonyms:
LIM15

Cilia effects upon perturbation of DMC1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Reproduction & sperm
  • Protein processing & maturation

Function

dmc1, which encodes an essential meiotic recombi tion protein, as the major target gene of E2f5 during spermatogenesis. E2f5 can bind to the promoter of dmc1 to promote homologous recombi tion, and overexpression of dmc1 significantly increased the fertilization rate of e2f5 mutant males ( 32196499).

Model organism evidence

Mus musculus (1 reference)

Our transcriptome analysis showed that there was not a remarkable change in the expression of most of the genes involved in the pathways associated with the meiotic DNA repair and flagella assembly.

PMIDs: 27480068