DMRT2

doublesex and mab-3 related transcription factor 2

Ensembl:
ENSG00000173253
UniProt:
Q9Y5R5
OMIM:
604935

Cilia effects upon perturbation of DMRT2

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.77) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

Fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment (19789708). DMRT2 localized to basal body (25613900). In dmrt2 morphants, cilia were substantially shortened.

Model organism evidence

Xenopus (1 reference)

Here, we show that doublesex and mab3-related transcription factor 2 (Dmrt2), known to be involved in vertebrate somitogenesis, is required for LRO ciliogenesis and sLRO specification.

PMIDs: 35813209