DNAAF10

dynein axonemal assembly factor 10

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000243667
UniProt:: Q96MX6
OMIM:: 610729
Synonyms:: FLJ31741, MONAD, WDR92

Subcellular localization

basal body, cilia

References: PMID:26912790, PMID:29743191, PMID:30428028, PMID:31116681

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

Highly conserved WD-repeat protein which acts as part of a chaperone complex involved in pre-assembly of axonemal dynein in the cytoplasm. Required for motile ciliogenesis in pla rian Schmidtea mediterranea, knockdowns have partial loss of dynein arms (26912790). Works with the D AF Spag1 at a distinct stage in dynein preassembly to regulate cytoplasmic pre- assembly of ciliary dynein in Drosophila (29743191). Functions with the HSP90 co-chaperone R2TP-like complex and other D AFs in axonemal dynein preassembly in the cytoplasm of Chlamydomonas (30428028). Stablises axonemal dynein heavy chains in cytoplasm in Chlamydomonas (31116681)

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