DNAH10

dynein axonemal heavy chain 10

Ensembl:
ENSG00000281935, ENSG00000197653
UniProt:
Q8IVF4
OMIM:
605884
Synonyms:
FLJ43808

Cilia effects upon perturbation of DNAH10

Ciliogenesis screen results (3 screens)

  • Kim2016: Not Reported
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse ciliopathy phenotype:
male infertility

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • T cell biology
  • Cell migration & adhesion

Function

Component of outer dynein arm (PMID:15937072, 11175280, 29843777). Heterotaxy candidate gene, involved in left-right patterning regulaton by affecting the notochord. Participates in protozoan flagellar motility (29843777)

Model organism evidence

Mus musculus (1 reference)

Light and electron microscopy showed numerous defects in the head-to-tail coupling apparatus of the sperm, and a small number of structural defects in the sperm flagella.

PMIDs: 40373254