DNAH12

dynein axonemal heavy chain 12

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000174844
UniProt:: Q6ZR08
OMIM:: 603340
Synonyms:: DHC3, DLP12, DNAH12L, DNAH7L, DNAHC3, DNHD2, FLJ40427, FLJ44290, HDHC3, HL-19

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

endosome, flagella

References: PMID:42010243, PMID:40146200

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism

Function

DNAH12 plays a crucial role in the proper organization of axoneme in flagella, but not cilia, by recruiting DNAH1 and DNALI1 in both humans and mice (40146200).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.