DNAH14

dynein axonemal heavy chain 14

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000185842
UniProt:
Q0VDD8
OMIM:
603341
Synonyms:
C1ORF67, DKFZP781B1548, DNAHC14, HL-18, HL18, MGC27277

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=2.09) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Ciliopathy associations

  • Primary Ciliary Dyskinesia

References: PMID:39004944

Subcellular localization

basal body, endoplasmic reticulum, transition zone

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Transition zone

Function

DNAH14 has localized in basal body, transition zone.