DNAH17

dynein axonemal heavy chain 17

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000187775
UniProt:: Q9UFH2
OMIM:: 610063
Synonyms:: DNAHL1, DNEL2, FLJ40457

Ciliogenesis screen results (1 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: abnormal hair growth

Ciliopathy associations

Male Infertility

References: PMID:38992144

Subcellular localization

cilia

References: PMID:31178125, PMID:31658987

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Reproduction & sperm
Cell migration & adhesion

Function

Sperm-specific axonemal outer dynein arm heavy chain. Mutations cause isolated male infertility due to asthenozoospermia (31178125) and flagella instability (31658987)

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