DNAH17

dynein axonemal heavy chain 17

Ensembl:
ENSG00000187775
UniProt:
Q9UFH2
OMIM:
610063
Synonyms:
DNAHL1, DNEL2, FLJ40457

Cilia effects upon perturbation of DNAH17

Ciliogenesis screen results (1 screen)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
abnormal hair growth
Mouse ciliopathy phenotype:
male infertility

Ciliopathy associations

  • Male Infertility

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Cell migration & adhesion

Function

Sperm-specific axonemal outer dynein arm heavy chain. Mutations cause isolated male infertility due to asthenozoospermia (31178125) and flagella instability (31658987)

Model organism evidence

Mus musculus (1 reference)

Moreover, the expression levels of Dnah8 and Dnah17, two genes associated with Multiple Morphological Abnormalities of the Flagella (MMAF), were markedly reduced in the HAT group.

PMIDs: 41437299