DNAH2

dynein axonemal heavy chain 2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000183914
UniProt:: Q9P225
OMIM:: 603333
Synonyms:: DNHD3, FLJ46675, KIAA1503

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: germ cell defect, developmental dysplasia, hypospermia, hyperactivity, rhinitis, abnormal semil vesicle morphology, abnormal lymph node morphology, spermatogenesis defect

Subcellular localization

cilia, flagella, basal body

References: PMID:41410385, PMID:42010243, PMID:41005307, PMID:30811583

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Reproduction & sperm
Cell migration & adhesion

Function

Component of axonemal inner dynein arm-f, essential for ciliary beat (30060180). DNAH2 mutation can cause severe sperm flagella defects that damage sperm motility (30811583).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.