DNAH3

dynein axonemal heavy chain 3

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000158486
UniProt:: Q8TD57
OMIM:: 603334
Synonyms:: DKFZP434N074, DLP3, DNAHC3B, HSADHC3

Ciliogenesis screen results (3 screens)

Kim2016: Not Reported
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

References: PMID:39503742

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
Reproduction & sperm
Cell migration & adhesion

Function

Dnah3 knockout (KO) male mice were also infertile, especially showing the severe reduction in sperm movement with the abnormal inner dynein arms and mitochondrion structure (39503742).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.