DNAH3

dynein axonemal heavy chain 3

Ensembl:: ENSG00000158486
UniProt:: Q8TD57
OMIM:: 603334
Synonyms:: DKFZP434N074, DLP3, DNAHC3B, HSADHC3

Cilia effects upon perturbation of DNAH3

Ciliogenesis screen results (3 screens)

Kim2016: Not Reported
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation
Metabolism
T cell biology
Reproduction & sperm
Cell migration & adhesion

Function

D h3 knockout (KO) male mice were also infertile, especially showing the severe reduction in sperm movement with the abnormal inner dynein arms and mitochondrion structure (39503742).

Model organism evidence

Mus musculus (1 reference)

DNAH3 deficiency causes flagellar inner dynein arm loss and male infertility in humans and mice.

PMIDs: 39503742

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